Streamlined process opens drug development to a new class of steroids.


Researchers at Dartmouth College have developed a technique to produce synthetic steroids that could pave the way for a cascade of new drug discoveries. The process facilitates access to rare, mirror-image isomers of naturally occurring steroid structures. The core molecular structure of steroids is a proven backbone in drug development. More than 100 different steroid molecules are approved by the U.S. Food and Drug Administration as therapeutics for a wide range of symptoms and diseases including inflammation and pain, cancer and bacterial infection.

Steroidal therapeutics arguably make up the most successful class of medicine inspired by a natural product. All known drugs in this class share a common structure comprised of only one of two possible mirror image skeletons - known as enantiomers. Such agents are typically available from chemical transformations of natural and readily available steroids. According to researchers, molecules based on the unnatural mirror image isomer of steroids form the foundation of a vast collection of underexplored potential medicines. While these compounds share the basic drug-like physical properties of the natural class, they boast complementary 3-D structures with broad potential in the clinic.

The science of synthetic organic chemistry is an essential component of drug discovery, and advances in this field are directly responsible for our recent discovery. Without the ability to create new collections of molecules, it is difficult to pursue many potentially exciting new directions in drug discovery. As such, advances in chemical synthesis, like this one, can have profound and rippling effects on biomedical science.

The Journal of Pharmaceutical Chemistry and Pharmacology aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Pharmaceutical chemistry and pharmacology emphasizing on synthetic organic chemistry. The open access journal is published by Pulsus. Established in the year 1984, Pulsus was focusing on American region and presently expanding to healthcare informatics platform to the medical and pharma professionals throughout Europe, America, Asia, Australia and all other continents. Since its inception, Pulsus received the endorsements of the medical associations and industries of the international reputation. This support allowed Pulsus Group to gain excellent reputation from the scientific and industrial community and able to bridge relations between industries and practicing physicians.

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Journal of Pharmaceutical Chemistry and Pharmacology


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