Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against rodent malaria

Image The liver is an important site of replication for Plasmodium parasites, and therefore a key goal in vaccination against malaria is to induce robust antiparasitic immunity in the liver. Using Plasmodium berghei as a model to study malaria in mice, Holz et al. have developed a glycolipid-peptide conjugate vaccine that induced robust T cell responses in the liver and was able to protect mice when challenged with P. berghei. Inclusion of the glycolipid adjuvant, α-galactosylceramide (α-GalCer) that activates natural killer T (NKT) cells was vital to promoting antiparasitic immunity ... Read More

Researcher's destroy cancer cells with ultrasound treatment.

Image An international research team led by Dr. Tali Ilovitsh of the Biomedical Engineering Department at Tel Aviv University developed a noninvasive technology platform for gene delivery into breast cancer cells. The technique combines ultrasound with tumor-targeted microbubbles. Once the ultrasound is activated, the microbubbles explode like smart and targeted warheads, creating holes in cancer cells' membranes, enabling gene delivery. Conducted over two years, the research was published on June 9 in the journal Proceedings of the National Academy of Sciences (PNAS). Dr. Ilovitsh ... Read More

Intravenous versus Subcutaneous Immunoglobulin in Primary Immunodeficiency: Real-World Evaluation of Safety, Efficacy, and Patient Perceptions

Image Background: Patients with primary immunodeficiency disorders (PIDD) typically require life-long immunoglobulin (IG) replacement therapy. There are two routes of IG administration: intravenous (IVIG) and subcutaneous (SCIG). To better understand routes of IG administration in the real-world, use in a home infusion setting was evaluated. Objective: To evaluate the safety, efficacy, and perceived responses in PIDD patients on IVIG versus SCIG in a realworld, home infusion setting. Methods: Retrospective data were collected from 2010 to 2018 from a national home infusion pharmacy of PIDD patien... Read More

This vaccine may protects against worst symptoms of COVID-19

Image The MMR (measles, mumps, rubella) vaccine could serve as a preventive measure to dampen septic inflammation associated with COVID-19 infection, say researchers. According to the study, published in the journal mBio, vaccination with MMR in immunocompetent individuals has no contraindications and may be especially effective for health care workers who can easily be exposed to COVID-19. "Live attenuated vaccines seemingly have some nonspecific benefits as well as immunity to the target pathogen. A clinical trial with MMR in high-risk populations may provide a low-risk... Read More

Systems Biology for Understanding Cancer Biology

Image During last decades the theoretical framework in carcinogenesis studies has been provided by the Somatic Mutation Theory (SMT). SMT envisions understanding cancer at the cellular level of organization, by claiming that cancer is a problem of regulatory control of cell proliferation and invasiveness, mainly due to mutations and/or deregulation of a specific class of genes Even though SMT has fostered a meaningful development of molecular-based technologies, on the other hand that approach has encompassed an increasing number of experimental results that contradict its premises .... Read More

Synthetic cell biology

Image The Current Synthetic and Systems Biology aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to like molecular biology, theoretical biology, structural biology, marine biology etc.. Synthesis of data into formal models of cellular function is rapidly becoming a necessary industry. The complexity of the interactions among cellular constituents and the quantity of data about these interactions hinders the ability to predict how cells will respond to perturbation and how they can be en... Read More

Durable Long-Term Responses in B-cell Lymphoma and Chronic Lymphocytic Leukemia After Anti-CD19 CAR T-Cell Therapy

Image Long-term follow-up of the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy in patients with B-cell lymphoma and chronic lymphocytic leukemia (CLL) demonstrated highly durable remissions with few long-term adverse effects. These findings were presented by Kathryn Cappell, MD, PhD, of the National Cancer Institute, during the ASCO20 Virtual Scientific Program. Between 2009 and 2015, the investigators conducted the first clinical trial (ClinicalTrials.gov Identifier: NCT00924326) of anti-CD19 CAR T cells that showed responses against lymphoma. The CAR from that trial, FMC63-... Read More

Allogenic CAR-T Cell Therapy Shows High Response Rate for Patients with Relapsed/Refractory B-Cell Lymphomas

Image The allogeneic chimeric antigen receptor (CAR)-T cell therapy ALLO-501, paired with the monoclonal antibody ALLO-647, showed clinical activity and a manageable safety profile in patients with relapsed/refractory large B-cell or follicular lymphoma. The first-in-human findings were presented during the virtual scientific program of the American Society of Clinical Oncology (ASCO) 2020 Annual Meeting. The two treatments were used sequentially in the open-label, phase 1 ALPHA study that occurred across six U.S. sites, demonstrating an overall response rate of 63%, including a 37% com... Read More

Rady Re-Evaluating Recent Kawasaki Cases For New Pediatric Illness Tied To Coronavirus

Image San Diego's Children's Hospital is reviewing patients it recently treated for Kawasaki disease to determine if they were actually suffering from a similar but rare new illness connected to the novel coronavirus. Doctors around the world, often in regions hit hardest by the pandemic, have reported cases of a pediatric inflammatory illness that can affect multiple organs, including the heart. The condition is like Kawasaki disease, which causes inflammation of the blood vessels but is appearing in children who have had some form of exposure to the SARS-CoV-2 virus. ... Read More

Factors regulating axon regeneration via JNK MAP kinase in Caenorhabditis elegans

Image Axon regeneration following nerve injury is a highly conserved process in animals. The nematode Caenorhabditis elegans is an excellent model for investigating the molecular mechanisms of axon regeneration. Recent studies using C. elegans have shown that the c-Jun N-terminal kinase (JNK) plays the important role in axon regeneration. Furthermore, many factors have been identified that act upstream of the JNK cascade after axotomy. This review introduces these factors and describes their roles during the regulation of axon regeneration. Most neurons have long processes called axons,... Read More

A novel dynein-type AAA+ protein with peroxisomal targeting signal type 2

Image Peroxisomal matrix proteins are imported into peroxisomes in a process mediated by peroxisomal targeting signal (PTS) type 1 and 2. The PTS2 proteins are imported into peroxisomes after binding with Pex7p. Niwa et al. (A newly isolated Pex7-binding, atypical PTS2 protein P7BP2 is a novel dynein-type AAA+ protein. J Biochem 2018;164:437–447) identified a novel Pex7p-binding protein in CHO cells and characterized the subcellular distribution and molecular properties of the human homologue, ‘P7BP2’. Interestingly, P7BP2 possesses PTS2 at the NH2 terminal and six putative AAA+... Read More

Advice on the use of point-of-care immunodiagnostic tests for COVID-19

Image In response to the growing COVID-19 pandemic and shortages of laboratory-based molecular testing capacity and reagents, multiple diagnostic test manufacturers have developed and begun selling rapid and easy-to-use devices to facilitate testing outside of laboratory settings. These simple test kits are based either on detection of proteins from the COVID-19 virus in respiratory samples (e.g. sputum, throat swab) or detection, in blood or serum, of human antibodies generated in response to infection. WHO applauds the efforts of test developers to innovate and respond to the needs of... Read More

Coronavirus disease (COVID-2019) R&D

Image The current COVID-19 pandemic is unprecedented, but the global response draws on the lessons learned from other disease outbreaks over the past several decades. As part of WHO’s response, the R&D Blueprint was activated to accelerate diagnostics, vaccines and therapeutics for this novel coronavirus. The Blueprint aims to improve coordination between scientists and global health professionals, accelerate the research and development process, and develop new norms and standards to learn from and improve upon the global response. On 30 January 2020, following the ... Read More

COVID-19 Vaccine "Largely Protected" Monkeys From Virus: Chinese Firm

Image Beijing: A novel coronavirus vaccine has for the first time "largely protected" monkeys from infection during an animal trial, data from a Chinese pharmaceutical giant showed. It is among a slew of vaccines being developed around the world as countries race to stop an outbreak that has infected around 2.7 million people globally and killed more than 190,000. Nasdaq-listed Sinovac Biotech said it injected two different doses of its vaccine into eight rhesus macaque monkeys and exposed them to the virus three weeks later, and they did not develop infections. ... Read More

Covid-19 vaccine: Oxford University to start human trials from today

Image Oxford University will start human testing with a Covid-19 vaccine they developed from Thursday, the UK government said in a coronavirus press conference. The Oxford team – led by Professor Sarah Gilbert, is testing ChAdOx1 nCoV-19, a candidate based on a chimpanzee adenovirus modified to include the spike or ‘S’ protein on the surface of SARS-CoV-2, the virus that causes Covid-19. The government funded the vaccine project with 20 million pounds to Oxford University and another 22 million pounds to a second vaccine project at Im... Read More

Coronaviruses found in two Indian bat species: ICMR study

Image As per a study by the Indian Council of Medical Research (ICMR), presence of a different kind of coronavirus has been found in two bat species in India. Researchers, however, said there is no evidence or research to claim that these bat coronaviruses can cause disease in humans. As the world grapples with coronavirus, researchers have found the presence of a different kind of coronavirus -- bat coronavirus (BtCoV) --in two bat species from Kerala, Himachal Pradesh, Puducherry and Tamil Nadu, according to a study by the Indian Council of Medical Research (ICMR). There is ... Read More

As COVID-19 forces world to quarantine, air quality has improved

Image As millions of people around the world quarantine in their homes to prevent the spread of COVID-19, research and photos show that quarantines appear to have made a positive, if unintended, impact on the environment. In February, air quality researches from NASA reported that there was a dramatic drop in nitrogen dioxide emissions coming from China, especially from Hubei province — the epicenter of the coronavirus pandemic. "This is the first time I have seen such a dramatic drop-off over such a wide area for a specific event," says Fei Liu, an air quality... Read More

Coronavirus: Chandigarh hospital plans plasma therapy trials to cure Covid-19 patients

Image HIGHLIGHTS PGIMER in Chandigarh is planning to conduct plasma trials to cure Covid-19 patients It is collaborating with another Covid-19 centre to launch plama trials PGIMER director Jagat Ram said plama therapy as Covid-19 cure holds promise The Post Graduate Institute of Medical Education and Research (PGIMER) in Chandigarh will soon launch trials for Plasma therapy for curing will test it in the COVID-19 patients. Dr Jagat Ram, Director, PGIMER, told India Today TV on Thursday that the institute will col... Read More

Journal of Biomolecules and Biochemistry: Volume 4 Issue 1| 2020

Image Journal of Biomolecules and Biochemistry is an open access, peer-reviewed journal that focuses on all aspects of Biomolecules and Biochemistry. Celebrating a successful publication history, PULJBB solicits research contributions pertaining to chemical, physical, mechanistic, and structural basis of biological or cell function, lipids, phospholipids, glycolipids, sterols, glycerolipids, carbohydrates, sugars, vitamins, hormones, neurotransmitters, metabolites, amino ... Read More

Dynamics and Endocytosis of Flot1 in Arabidopsis Require CPI1 Function

Image Membrane microdomains are nano-scale domains (10–200 nm) enriched in sterols and sphingolipids. They have many important biological functions, including vesicle transport, endocytosis, and pathogen invasion. A previous study reported that the membrane microdomain-associated protein Flotillin1 (Flot1) was involved in plant development in Arabidopsis thaliana; however, whether sterols affect the plant immunity conveyed by Flot1 is unknown.   ... Read More

Functional Cyclization of Eukaryotic mRNAs

Image The closed-loop model of eukaryotic translation states that mRNA is circularized by a chain of the cap-eIF4E-eIF4G-poly(A)-binding protein (PABP)-poly(A) interactions that brings 5′ and 3′ ends together. This circularization is thought to promote the engagement of terminating ribosomes to a new round of translation at the same mRNA molecule, thus enhancing protein synthesis. Despite the general acceptance and the elegance of the hypothesis, it has never been proved experimentally.  ... Read More

WHO launches global megatrial of the four most promising coronavirus treatments

Image Could any of these drugs hold the key to saving coronavirus disease 2019 (COVID-19) patients from serious harm or death? On Friday, the World Health Organization (WHO) announced a large global trial, called SOLIDARITY, to find out whether any can treat infections with the new coronavirus for the dangerous respiratory disease. It’s an unprecedented effort—an all-out, coordinated push to collect robust scientific data rapidly during a pandemic. The study, which could include many thousands of patients in dozens of countries, has been designed to be as simple as possible so that ev... Read More

New coronavirus stable for hours on surfaces

Image The virus that causes coronavirus disease 2019 (COVID-19) is stable for several hours to days in aerosols and on surfaces, according to a new study from National Institutes of Health, CDC, UCLA and Princeton University scientists in The New England Journal of Medicine. The scientists found that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detectable in aerosols for up to three hours, up to four hours on copper, up to 24 hours on cardboard and up to two to three days on plastic and stainless steel. The results provide key information about the stability of S... Read More

Systems biology approaches to the analysis of how the intracellular networks of normal cells are perturbed during carcinogenesis

Image We are pleasure to introduce our Journal of Molecular Cancer encourages researchers and gives more important for the manuscripts with updated information related to the journal. Our journal accepts papers in the form of protocols/research article/review/case report/mini-review/short commentary, etc. Cancer systems biology encompasses the application of systems biology approaches to cancer research, in order to study the d... Read More

Self-assembling, donut-shaped nanoparticles form novel platform for development of new biomolecules

Image In work published recently in Nature Structural & Mechanical Biology, scientists at Fred Hutchinson Cancer Research Center described self-assembling, donut-shaped protein nanoparticles designed from scratch. The team showed that the nanoparticles, which can act as scaffolds for the organization and display of biomolecules currently used in various clinical and research applications, could someday ... Read More

Researchers identify potential coronavirus vaccines and therapy targets

Image Researchers show that antibodies that can neutralize the virus that causes SARS can reduce how well the new coronavirus infects cells in laboratory studies. They also use an approved drug to reduce virus entry into cells. With global cases of COVID-19 surpassing 100,000, researchers are looking for ways to prevent new viral infections. The new coronavirus, called SARS-CoV-2, has strong similarities to other viruses in the coronavirus family, particularly those that cause SARS and MERS. Two new papers appeared recently in the journal Cell, investig... Read More

THE DARK MOLECULAR GAS

Image The mass of molecular gas in an interstellar cloud is often measured using line emission from low rotational levels of CO, which are sensitive to the CO mass, and then scaling to the assumed molecular hydrogen H2 mass. However, a significant H2 mass may lie outside the CO region, in the outer regions of the molecular cloud where the gas-phase carbon resides in C or C+. Here, H2 self-shields or is shielded by dust from UV photodissociation, whereas CO is photodissociated. This H2 gas is “dark” in molecular transitions because of the absence of CO and other trace molecules, and be... Read More

Tiny Blood Testing Device Can Detect Coronavirus At The Airport - Researchers Claim

Image Researchers at the AES Venture in Masdar City, Abu Dabhi, have developed a new device claiming that it would help in detecting viruses such as coronavirus just like a pregnancy or a diabetes sugar test. The company also claims that the detection could be done through a simple blood test which would be conducted on passengers at the UAE airport during arrival and that the results would be shared in real-time within a few minutes. The company has called the device ‘The Reader’ and stated that it has a mechanism to extract blood and share its findings with the health auth... Read More

Researchers identify potential coronavirus vaccine and therapy targets

Image Researchers show that antibodies that can neutralize the virus that causes SARS can reduce how well the new coronavirus infects cells in laboratory studies. They also use an approved drug to reduce virus entry into cells. The new coronavirus, SARS-CoV-2, is a type of virus called an enveloped RNA virus. This means that its genetic material is encoded in single-stranded RNA molecules surrounded by a cell membrane taken from the cell that it last infected. When enveloped viruses infect a cell, they do this using a two-stage process. The first step invol... Read More

Molecular Electronic Devices Based on Single-Walled Carbon Nanotube Electrodes

Image As the top-down fabrication techniques for silicon-based electronic materials have reached the scale of molecular lengths, researchers have been investigating nanostructured materials to build electronics from individual molecules. Researchers have directed extensive experimental and theoretical efforts toward building functional optoelectronic devices using individual organic molecules and fabricating metal−molecule junctions. Although this method has many advantages, its limitations lead to large disagreement between experimental and theoretical results. This Account descr... Read More

Chromosomal Microarray Analysis Uncovers Pathogenic Copy Number Variations in Unexplained Neurodevelopmental Disorders and Congenital Anomalies

Image Background: Neurodevelopmental disorders represent a broad spectrum of cognitive, neurological, and/or psychiatric dysfunction caused by impairment of the brain during development. The present deals with the chromosomal rearrangements in patients with neurodevelopmental disorders, Developmental Delay/ Intellectual Disability (DD/ID) and/or congenital anomalies employing Chromo... Read More

The ‘mitochondrial contact site and cristae organising system’ (MICOS) in health and human disease

Image The ‘mitochondrial contact site and cristae organising system’ (MICOS) is an essential protein complex that promotes the formation, maintenance and stability of mitochondrial cristae. As such, loss of core MICOS components disrupts cristae structure and impairs mitochondrial function. Aberrant mitochondrial cristae morphology and diminished mitochondrial function is a pathological hallmark observed across many human diseases such as neurodegenerative conditions, obesity and diabetes mellitus, cardiomyopathy, and in muscular dystrophies and myopathies. While mitochondrial abnorma... Read More

PINK1 import regulation at a crossroad of mitochondrial fate: the molecular mechanisms of PINK1 import

Image PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase whose activity is tightly regulated by the mitochondrial health status. In response to mitochondrial damage, activated PINK1 can promote mitophagy, an autophagic elimination of damaged mitochondria, by cooperating with Parkin ubiquitin ligase. Loss-of-function of PINK1/Parkin-mediated mitophagy results in the accumulation of dysfunctional mitochondria, which could be one aetiology of Parkinson’s disease (PD). Within step-by-step signalling cascades of PINK1/Parkin-mediated mitophagy, mitochondrial damage-dependent PINK1 kinase ac... Read More

Animations and Simulations for Teaching and Learning Molecular Chemistry

Image Animated visualizations that show both structures and processes help teachers convey important scientific concepts in chemistry and molecular biology. Designers of these animations benefit from knowing how students perceive and comprehend such visualizations. Specifically, instructional developers seek to design visualizations that allow students to learn critical concepts and relationships between these concepts. Students learn molecular chemistry concepts and relations by attending to, seeing, and understanding all the associated elements and the ways that they change and evolve during th... Read More

Bioinformatics Approaches to the Understanding of Molecular Mechanisms in Antimicrobial Resistance

Image Antimicrobial resistance (AMR) is a major health concern worldwide. A better understanding of the underlying molecular mechanisms is needed. Advances in whole genome sequencing and other high-throughput unbiased instrumental technologies to study the molecular pathogenicity of infectious diseases enable the accumulation of large amounts of data that are amenable to bioinformatic analysis and the discovery of new signatures of AMR. In this work, we review representative methods published in the past five years to define major approaches developed to-date in the understanding of AMR m... Read More

Journal of Biomolecules and Biochemistry: Open Access

Image Journal of Biomolecules and Biochemistry is an open access peer-reviewed broad scope journal publishes original articles, reviews, commentaries, short communications, case reports, editorials, letter to editor and Perspective articles.  Our aim is to encourage scientists to publish their latest experiments on major topics like biological chemistry, small molecules, monomers, polymers, biochemistry, cellular biosciences and molecular biology. Journal mainly focusing on biogenic substances and their biological structures, functions, interactions with other molecul... Read More

Journal of Biomolecules and Biochemistry-Long Journey by Announcing Discounts on Article Processing Charges

Image Journal of Biomolecules and Biochemistry is an open access peer-reviewed broad scope journal publishes original articles, reviews, commentaries, short communications, case reports, editorials, letter to editor and Perspective articles.  Our aim is to encourage scientists to publish their latest experiments on major topics like biological chemistry, small molecules, monomers, polymers, biochemistry, cellular biosciences and molecular biology. Journal mainly focusing on biogenic substances and their biological structures, functions, interactions with other molecul... Read More

Molecular Basis and Engineering of Enzymes Stereospecificity

Image Molecular recognition, particularly enantiomeric specificity of biological molecules is a key consideration in designing drugs, pharmaceutical intermediate and in industrial production of chirally active intermediate. Although the molecular bases of many enzymes stereospecificity are not completely delineated, a number of protein engineering studies were able to enhance and even in some cases invert the stereospecificity of various enzymes. Herein, we review the current understanding on enzymes stereospecificity, and the effects of mutations to the stereospecific pockets due to enzymes engi... Read More

Molecular Biophysics

Image Journal of Molecular science is an official peer reviewed journal for the rapid publication of innovative research covering all aspects of molecular sciences and providing an advanced forum for molecular biology, molecular medicine and chemistry. Molecular Sciences is an integrative, complex, concerted and a multidisciplinary science dealing with the study of different type of molecules.It includes a wide range of fields in its discipline to create a platform for the authors to make their contribution towards the journal and the editorial office promises a peer review proce... Read More

RESEARCH ON BIOMOLECULES AND BIOCHEMISTRY: JOURNAL OF BIOMOLECULES AND BIOCHEMISTRY (PULJBB)

Image Journal of Biomolecules and Biochemistry is an open access peer-reviewed broad scope journal publishes original articles, reviews, commentaries, short communications, case reports, editorials, letter to editor and Perspective articles. Our aim is to encourage scientists to publish their latest experiments on major topics like biological chemistry, small molecules, monomers, polymers, biochemistry, cellular biosciences and molecular biology. Journal mainly focusing on biogenic substances and their biological structures, functions, interactions with other molecules, and their mi... Read More

JOURNAL OF BIOMOLECULES AND BIOCHEMISTRY (PULJBB): GLOBALISE YOUR RESEARCH WORK

Image Journal of Biomolecules and Biochemistry is an open access peer-reviewed broad scope journal publishes original articles, reviews, commentaries, short communications, case reports, editorials, letter to editor and Perspective articles. Our aim is to encourage scientists to publish their latest experiments on major topics like biological chemistry, small molecules, monomers, polymers, biochemistry, cellular biosciences and molecular biology. Journal mainly focusing on biogenic substances and their biological structures, functions, interactions with other molecules, and their mi... Read More

Journal of Biomolecules and Biochemistry Invites Manuscripts

Image Journal of Biomolecules and Biochemistry is a scholarly Open Access journal which provides comprehensive coverage of modern practices in Biomolecules and Biochemistry. Articles are welcome in the form of research articles, review articles, case reports, short communications and commentaries on relevant topics. The editorial office ensures a rigorous peer review process for the submitted manuscripts for maintaining the quality of publishing and in achieving high journal i... Read More

Journal of Biomolecules and Biochemistry Invites Active Reviewers

Image The Journal of Biomolecules and Biochemistry is a scholarly Open Access journal which provides comprehensive coverage of modern practices in Biomolecules and Biochemistry. Articles are welcome in the form of research articles, review articles, case reports, short communications and commentaries on relevant topics. The editorial office ensures a rigorous peer review process for the submitted manuscripts for maintaining the quality of publishing and in achieving high journal impact factor. Now the Journal is inviting active reviewers to review our articles. We will honour ... Read More

Journal of Biomolecules and Biochemistry-Open Access

Image The Journal of Biomolecules and Biochemistry is a scholarly Open Access journal which provides comprehensive coverage of modern practices in Biomolecules and Biochemistry. Articles are welcome in the form of research articles, review articles, case reports, short communications and commentaries on relevant topics. The editorial office ensures a rigorous peer review process for the submitted manuscripts for maintaining the quality of publishing and in achieving high journal impact factor. Editor-in-Chief Higo Nasser is supported by an outstanding Editorial Board of... Read More