Systems biology approaches to the analysis of how the intracellular networks of normal cells are perturbed during carcinogenesis

Image We are pleasure to introduce our Journal of Molecular Cancer encourages researchers and gives more important for the manuscripts with updated information related to the journal. Our journal accepts papers in the form of protocols/research article/review/case report/mini-review/short commentary, etc. Cancer systems biology encompasses the application of systems biology approaches to cancer research, in order to study the d... Read More

Self-assembling, donut-shaped nanoparticles form novel platform for development of new biomolecules

Image In work published recently in Nature Structural & Mechanical Biology, scientists at Fred Hutchinson Cancer Research Center described self-assembling, donut-shaped protein nanoparticles designed from scratch. The team showed that the nanoparticles, which can act as scaffolds for the organization and display of biomolecules currently used in various clinical and research applications, could someday ... Read More

Researchers identify potential coronavirus vaccines and therapy targets

Image Researchers show that antibodies that can neutralize the virus that causes SARS can reduce how well the new coronavirus infects cells in laboratory studies. They also use an approved drug to reduce virus entry into cells. With global cases of COVID-19 surpassing 100,000, researchers are looking for ways to prevent new viral infections. The new coronavirus, called SARS-CoV-2, has strong similarities to other viruses in the coronavirus family, particularly those that cause SARS and MERS. Two new papers appeared recently in the journal Cell, investig... Read More

THE DARK MOLECULAR GAS

Image The mass of molecular gas in an interstellar cloud is often measured using line emission from low rotational levels of CO, which are sensitive to the CO mass, and then scaling to the assumed molecular hydrogen H2 mass. However, a significant H2 mass may lie outside the CO region, in the outer regions of the molecular cloud where the gas-phase carbon resides in C or C+. Here, H2 self-shields or is shielded by dust from UV photodissociation, whereas CO is photodissociated. This H2 gas is “dark” in molecular transitions because of the absence of CO and other trace molecules, and be... Read More

Tiny Blood Testing Device Can Detect Coronavirus At The Airport - Researchers Claim

Image Researchers at the AES Venture in Masdar City, Abu Dabhi, have developed a new device claiming that it would help in detecting viruses such as coronavirus just like a pregnancy or a diabetes sugar test. The company also claims that the detection could be done through a simple blood test which would be conducted on passengers at the UAE airport during arrival and that the results would be shared in real-time within a few minutes. The company has called the device ‘The Reader’ and stated that it has a mechanism to extract blood and share its findings with the health auth... Read More

Researchers identify potential coronavirus vaccine and therapy targets

Image Researchers show that antibodies that can neutralize the virus that causes SARS can reduce how well the new coronavirus infects cells in laboratory studies. They also use an approved drug to reduce virus entry into cells. The new coronavirus, SARS-CoV-2, is a type of virus called an enveloped RNA virus. This means that its genetic material is encoded in single-stranded RNA molecules surrounded by a cell membrane taken from the cell that it last infected. When enveloped viruses infect a cell, they do this using a two-stage process. The first step invol... Read More

Molecular Electronic Devices Based on Single-Walled Carbon Nanotube Electrodes

Image As the top-down fabrication techniques for silicon-based electronic materials have reached the scale of molecular lengths, researchers have been investigating nanostructured materials to build electronics from individual molecules. Researchers have directed extensive experimental and theoretical efforts toward building functional optoelectronic devices using individual organic molecules and fabricating metal−molecule junctions. Although this method has many advantages, its limitations lead to large disagreement between experimental and theoretical results. This Account descr... Read More

Chromosomal Microarray Analysis Uncovers Pathogenic Copy Number Variations in Unexplained Neurodevelopmental Disorders and Congenital Anomalies

Image Background: Neurodevelopmental disorders represent a broad spectrum of cognitive, neurological, and/or psychiatric dysfunction caused by impairment of the brain during development. The present deals with the chromosomal rearrangements in patients with neurodevelopmental disorders, Developmental Delay/ Intellectual Disability (DD/ID) and/or congenital anomalies employing Chromo... Read More

The ‘mitochondrial contact site and cristae organising system’ (MICOS) in health and human disease

Image The ‘mitochondrial contact site and cristae organising system’ (MICOS) is an essential protein complex that promotes the formation, maintenance and stability of mitochondrial cristae. As such, loss of core MICOS components disrupts cristae structure and impairs mitochondrial function. Aberrant mitochondrial cristae morphology and diminished mitochondrial function is a pathological hallmark observed across many human diseases such as neurodegenerative conditions, obesity and diabetes mellitus, cardiomyopathy, and in muscular dystrophies and myopathies. While mitochondrial abnorma... Read More

PINK1 import regulation at a crossroad of mitochondrial fate: the molecular mechanisms of PINK1 import

Image PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase whose activity is tightly regulated by the mitochondrial health status. In response to mitochondrial damage, activated PINK1 can promote mitophagy, an autophagic elimination of damaged mitochondria, by cooperating with Parkin ubiquitin ligase. Loss-of-function of PINK1/Parkin-mediated mitophagy results in the accumulation of dysfunctional mitochondria, which could be one aetiology of Parkinson’s disease (PD). Within step-by-step signalling cascades of PINK1/Parkin-mediated mitophagy, mitochondrial damage-dependent PINK1 kinase ac... Read More

Animations and Simulations for Teaching and Learning Molecular Chemistry

Image Animated visualizations that show both structures and processes help teachers convey important scientific concepts in chemistry and molecular biology. Designers of these animations benefit from knowing how students perceive and comprehend such visualizations. Specifically, instructional developers seek to design visualizations that allow students to learn critical concepts and relationships between these concepts. Students learn molecular chemistry concepts and relations by attending to, seeing, and understanding all the associated elements and the ways that they change and evolve during th... Read More

Bioinformatics Approaches to the Understanding of Molecular Mechanisms in Antimicrobial Resistance

Image Antimicrobial resistance (AMR) is a major health concern worldwide. A better understanding of the underlying molecular mechanisms is needed. Advances in whole genome sequencing and other high-throughput unbiased instrumental technologies to study the molecular pathogenicity of infectious diseases enable the accumulation of large amounts of data that are amenable to bioinformatic analysis and the discovery of new signatures of AMR. In this work, we review representative methods published in the past five years to define major approaches developed to-date in the understanding of AMR m... Read More

Journal of Biomolecules and Biochemistry: Open Access

Image Journal of Biomolecules and Biochemistry is an open access peer-reviewed broad scope journal publishes original articles, reviews, commentaries, short communications, case reports, editorials, letter to editor and Perspective articles.  Our aim is to encourage scientists to publish their latest experiments on major topics like biological chemistry, small molecules, monomers, polymers, biochemistry, cellular biosciences and molecular biology. Journal mainly focusing on biogenic substances and their biological structures, functions, interactions with other molecul... Read More

Journal of Biomolecules and Biochemistry-Long Journey by Announcing Discounts on Article Processing Charges

Image Journal of Biomolecules and Biochemistry is an open access peer-reviewed broad scope journal publishes original articles, reviews, commentaries, short communications, case reports, editorials, letter to editor and Perspective articles.  Our aim is to encourage scientists to publish their latest experiments on major topics like biological chemistry, small molecules, monomers, polymers, biochemistry, cellular biosciences and molecular biology. Journal mainly focusing on biogenic substances and their biological structures, functions, interactions with other molecul... Read More

Molecular Basis and Engineering of Enzymes Stereospecificity

Image Molecular recognition, particularly enantiomeric specificity of biological molecules is a key consideration in designing drugs, pharmaceutical intermediate and in industrial production of chirally active intermediate. Although the molecular bases of many enzymes stereospecificity are not completely delineated, a number of protein engineering studies were able to enhance and even in some cases invert the stereospecificity of various enzymes. Herein, we review the current understanding on enzymes stereospecificity, and the effects of mutations to the stereospecific pockets due to enzymes engi... Read More

Molecular Biophysics

Image Journal of Molecular science is an official peer reviewed journal for the rapid publication of innovative research covering all aspects of molecular sciences and providing an advanced forum for molecular biology, molecular medicine and chemistry. Molecular Sciences is an integrative, complex, concerted and a multidisciplinary science dealing with the study of different type of molecules.It includes a wide range of fields in its discipline to create a platform for the authors to make their contribution towards the journal and the editorial office promises a peer review proce... Read More

RESEARCH ON BIOMOLECULES AND BIOCHEMISTRY: JOURNAL OF BIOMOLECULES AND BIOCHEMISTRY (PULJBB)

Image Journal of Biomolecules and Biochemistry is an open access peer-reviewed broad scope journal publishes original articles, reviews, commentaries, short communications, case reports, editorials, letter to editor and Perspective articles. Our aim is to encourage scientists to publish their latest experiments on major topics like biological chemistry, small molecules, monomers, polymers, biochemistry, cellular biosciences and molecular biology. Journal mainly focusing on biogenic substances and their biological structures, functions, interactions with other molecules, and their mi... Read More

JOURNAL OF BIOMOLECULES AND BIOCHEMISTRY (PULJBB): GLOBALISE YOUR RESEARCH WORK

Image Journal of Biomolecules and Biochemistry is an open access peer-reviewed broad scope journal publishes original articles, reviews, commentaries, short communications, case reports, editorials, letter to editor and Perspective articles. Our aim is to encourage scientists to publish their latest experiments on major topics like biological chemistry, small molecules, monomers, polymers, biochemistry, cellular biosciences and molecular biology. Journal mainly focusing on biogenic substances and their biological structures, functions, interactions with other molecules, and their mi... Read More

Journal of Biomolecules and Biochemistry Invites Manuscripts

Image Journal of Biomolecules and Biochemistry is a scholarly Open Access journal which provides comprehensive coverage of modern practices in Biomolecules and Biochemistry. Articles are welcome in the form of research articles, review articles, case reports, short communications and commentaries on relevant topics. The editorial office ensures a rigorous peer review process for the submitted manuscripts for maintaining the quality of publishing and in achieving high journal i... Read More

Journal of Biomolecules and Biochemistry Invites Active Reviewers

Image The Journal of Biomolecules and Biochemistry is a scholarly Open Access journal which provides comprehensive coverage of modern practices in Biomolecules and Biochemistry. Articles are welcome in the form of research articles, review articles, case reports, short communications and commentaries on relevant topics. The editorial office ensures a rigorous peer review process for the submitted manuscripts for maintaining the quality of publishing and in achieving high journal impact factor. Now the Journal is inviting active reviewers to review our articles. We will honour ... Read More

Journal of Biomolecules and Biochemistry-Open Access

Image The Journal of Biomolecules and Biochemistry is a scholarly Open Access journal which provides comprehensive coverage of modern practices in Biomolecules and Biochemistry. Articles are welcome in the form of research articles, review articles, case reports, short communications and commentaries on relevant topics. The editorial office ensures a rigorous peer review process for the submitted manuscripts for maintaining the quality of publishing and in achieving high journal impact factor. Editor-in-Chief Higo Nasser is supported by an outstanding Editorial Board of... Read More