Journal of Molecular Cancer is an open access, peer reviewed, scholarly journal that aims to enhance our understanding on the genesis, diagnosis, consequences of cancer molecules by critiquing the literature on Molecular Cancer, Cell and Tumor Biology, Angiogenesis, Cancer Antigens, Cellular Signaling and Molecular Biology, Genetic And Molecular Profiling of Cancer, DNA Damage and Repair, Cell Cycle, Metastasis.

When the amount of proteins excreted in the urine exceeds the liver's ability to compensate, fewer proteins are detected in the blood – in particular albumin, which makes up the majority of circulating proteins. The association of cancer with glomerulonephritis is well known, in Detailed. Most forms of glomerulonephritis have been implicated: minimal change disease, membranous nephropathy, focal segmental glomerulosclerosis, mesangioproliferative GN, membranoproliferative GN (also known as mesangiocapillary GN) anti-GBM disease and ANCA-related vasculitis. Similarly, a large number of cancer forms have been implicated, including lung, colorectal, stomach, renal, bladder, prostate, gynaecologic, breast, thymoma, Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, and leukaemia. However, most of these associations are based on small series, with a limited number of cancer cases, which do not permit statistical analysis. The relationship of MN to cancer, primarily solid tumours is the best documented, with a number of large series. A metaanalysis showed a prevalence of 10%, primarily lung, prostate, haematological and colorectal.

Few population-based studies are available. The association of proteinuria with increased later cancer risk is well documented. In a Norwegian national study of 161 patients with MN, the cancer incidence after biopsy times the expected rate. Follow-up for 15 years did not seem to show a declining incidence. The largest population-based study was a Danish national study of all GN forms for the years. This revealed 102 cancers in 1958 patients during a follow-up period of average 4.7 years, 1.93 times the expected value. Increased rates were seen for MCD, endocapillary GN (EndGN), MN, MesPGN, and unclassified GN. Cancers with increased rates were lung, skin, lymphatic and haematological, non-Hodgkin lymphoma, Hodgkin’s disease and leukaemia. Haematological malignancy in particular was 7–17 times more common than expected.

Regards,
John George
Associate Editor
Journal of Molecular cancer