Human Immuno Deficiency Virus
The Journal of Immune Disorder and Therapy is a peer-reviewed, open access Journal aims to publish the latest developments in Autoimmune diseases, Rheumatology, Dermatology, Endocrinology, Molecular genetics, Cell biology etc. Immune system has long been recognized as the authoritative reference for the most current, clinically relevant and highest quality research in the field of immunology.
Gist of the study:
Anti-retroviral therapy (ART) has successfully helped managing HIV/ AIDS, but lead to emergence of HIVDR mutations. Failing ART among people living with HIV (PLHIV) increases the possibility of emergence of HIVDR. Failing second line ART necessitates the need of third-line ART. HIV viral load (VL) assessment is crucial requirement in ART programme. World Health Organization (WHO) advocates HIV VL monitoring to identify virologic failure as an early and precise indication of ART failure. Consequent corrective procedures would reduce accumulation of drug-resistance mutations and improve clinical outcomes. However, VL testing is not routinely done in many countries due to high cost and lack of facility. HIV epidemic is nearing four decades with different ART regimens. Thus, anti-retroviral (ARV) drug resistant viruses in treatment-experienced patients are also being encountered increasingly The second line ART regimens constitute zidovudine (ZDV), lamivudine (3TC), tenofovir (TDF), and boosted lopinavir/ritonavir (LPV/r). These were introduced in India in a restricted phase wise manner
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