Grooming the Pharmacological Boundaries for Drug Discovery and Development
Journal of Clinical Pharmacology and Toxicology expresses gratitude to all its elite panel of editorial board members for their continuous efforts, support and encouragement throughout journey of the journal, right from its inception in the year 2018 and congratulates them for making the journal achieve its goals and becoming successful and well-recognized broadcaster of scientific outcomes and perspectives from systematic inquiry into infectious diseases, medicine, and its related field.
Toxicology and Pharmacology
The connected discipline of toxicology includes the study of the nature and mechanisms of deleterious effects of chemicals on living beings. The study of toxicology as a distinct, yet related, discipline to pharmacology highlights the emphasis of toxicologists in formulating measures aimed at protective public health against exposures associated with toxic materials in food, air and water, as well as hazards that may be related with drugs. The word “pharmacology” itself comes from the Greek word. Pharmacology not only includes the sighting of drugs, but also the study of their biochemical properties, mechanisms of action, uses and biological effects.
Advances in Pharmacological Research
Liposomes and nanoparticles: Nanoscale drug delivery systems using liposomes and nanoparticles are rising technologies for the rational delivery of chemotherapeutic drugs in the treatment various ailments. Nanoparticles present possible dangers, both medically and environmentally.
The pharmaceutical industry is directly impacted by the research conducted with prescription drugs, vaccines, and OTC drugs being manufactured based on findings from the study of life sciences. Clinical trials are conducted to ensure that products being developed are tested on how well they work on individuals affected by the diseases or conditions they are created to treat.
It is based on principles of drug action. Biochemical pharmacology uses the methods of biochemistry, biophysics, molecular biology, structural biology, cell biology, and cell physiology to define the mechanisms of drug action and how drugs influence the organism by studies on intact animals, organs, cells, sub cellular compartments and individual protein molecules. It explores the range of biochemical targets and mechanisms. It covers research on the pharmacodynamics and pharmacokinetics of drugs and non-therapeutic xenobiotics. It also involves in elucidation of cellular and tissue functions at the biochemical and molecular levels, the modification of cellular phenotypes by genetic, transcriptional or translational or drug or compound-induced modifications.
Pharmacoepidemiology and Pharmaco-economics
Pharmacoepidemiology is the study of the utilization and effects of drugs in large numbers of people; it provides an estimate of the probability of beneficial effects of a drug in a population and the probability of adverse effects. It can be called a bridge science spanning both clinical pharmacology and epidemiology. Pharmacoepidemiology concentrates on clinical patient outcomes from therapeutics by using methods of clinical epidemiology and applying them to understanding the determinants of beneficial and adverse drug effects, effects of genetic variation on drug effect, duration-response relationships, clinical effects of drug-drug interactions, and the effects of medication non-adherence. Pharmacovigilance is a part of Pharmacoepidemiology that involves continual monitoring, in a population, for unwanted effects and other safety concerns arising in drugs that are already on the market. Pharmacoepidemiology sometimes also involves the conduct and evaluation of programmatic efforts to improve medication use on a population basis.
Development of medication is a vital concern to medicine. The metabolic stability and the reactivity of a library of candidate drug compounds must be assessed for drug metabolism and toxicological studies. Many methods of pharmacological tests have been proposed for quantitative predictions in drug metabolism. If the chemical structure of a medicinal compound is altered to some extent, this could slightly or noticeably alter the medicinal properties of the compound based on the level of alteration as it relates to the structural composition of the substrate or receptor site on which it exerts its medicinal effect, a concept referred to as the structural activity relationship (SAR). When a useful activity has been identified, chemists will make many similar compounds called analogues, to maximize the desired medicinal effect(s) of the compound.
Journal of Clinical Pharmacology and Toxicology is using Editorial Tracking System to maintain quality and transparency to the author in the peer-review process. Review processing will be performed by the editorial board members of the Journal of Clinical Pharmacology and Toxicology or by Reviewers (outside experts in the field). Two independent reviewer’s approval (Minimum reviewer’s approval) followed by editor approval is obligatory for acceptance of any manuscript excluding an editorial.
On the occasion of its 3 years, Successful Journey, Journal of Clinical Pharmacology and Toxicology decided to provide a partial waiver on its article processing charges to promote quality research from across the nations of the globe to encourage the latest research in the field of Infections, Diseases and Medicine. Journal of Clinical Pharmacology and Toxicology also planning to release a special issue on its new approaches.
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